TYPE A PRE-EXCITATION PATTERN INITIALLY DIAGNOSED AS ANXIETY: THE IMPORTANCE OF ECG IN PRIMARY CARE.

Authors

Download

Abstract

The pattern of pre-excitation associated with an accessory pathway is a relevant cause of palpitations and tachyarrhythmias in young adults, especially when it is not recognized promptly at the primary care level. The objective of this report is to describe the clinical presentation, the diagnostic process, and the evolution of a patient with an electrocardiographic pattern compatible with Type A pre-excitation, initially interpreted as an anxiety disorder. A review of the patient's clinical history, physical examination, and complementary studies was performed. We present the case of a 29-year-old man with intermittent episodes of sudden-onset palpitations, lasting from seconds to minutes, occasionally accompanied by dyspnea and a sensation of distress. In a previous evaluation, he had been categorized as having an anxiety disorder without complete criteria. The resting electrocardiogram showed a short PR interval, initial QRS slurring (delta wave), and secondary repolarization abnormalities, findings suggestive of a Type A pre-excitation pattern. The patient was referred to electrophysiology, where a left-sided accessory pathway was confirmed, and successful ablation was performed, leading to complete resolution of symptoms. This case highlights the importance of systematic electrocardiogram interpretation in primary care and reinforces the need to consider cardiological causes in young patients with palpitations before concluding a psychiatric diagnosis.

Keywords:

Wolff-Parkinson-White syndrome , cardiac arrhythmia , electrocardiography , primary health care , anxiety disorders

References

Munger TM, Packer DL, Hammill SC, Feldman BJ, Bailey KR, Ballard DJ, et al. A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953–1989. Circulation. 1993;87(3):866–873. doi:10.1161/01.CIR.87.3.866.

Wolff L, Parkinson J, White PD. Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachycardia. Ann Noninvasive Electrocardiol. 2006;11(4):340–353. doi:10.1111/j.1542-474X.2006.00127.x.

Kobza R, Toggweiler S, Dillier R, Abächerli R, Cuculi F, Sarraj A, et al. Prevalence of pre-excitation in a young population of male Swiss conscripts. Pacing Clin Electrophysiol. 2011;34(8):949–953. doi:10.1111/j.1540-8159.2011.03085.x.

Haïssaguerre M, Shah D, Jais P, Weerasooriya R, Fischer B, Nodari S, et al. Electrophysiological features and catheter ablation of accessory pathways--state of the art. Eur Heart J. 2020;41(2):135–142. doi:10.1093/eurheartj/ehz856.

Kim YG, Uhm JS, Lee HJ, Pak HN, Joung B. Sudden cardiac death risk in Wolff-Parkinson-White syndrome: current perspectives. JACC Clin Electrophysiol. 2019;5(1):1–9. doi: 10.1016/j.jacep.2018.08.010.

Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2018;138(13):e272–e391. doi:10.1161/CIR.0000000000000549.

Andrade JG, Verma A, Macle L, Nair GM, Deyell MW, Champagne J, et al. 2020 CCS/CHRS guideline for the management of atrial fibrillation: focused update for preexcitation and accessory pathways. Can J Cardiol. 2020;36(12):1847–1928. doi: 10.1016/j.cjca.2020.09.001.

Boriani G, Proietti M, Diemberger I, Martignani C, Biffi M. Diagnostic value of symptoms and ECG in identifying arrhythmias misdiagnosed as anxiety disorders. J Clin Med. 2021;10(3):547. doi:10.3390/jcm10030547.

Chen T, Zhang Z, Li X, et al. Misdiagnosis rate and determinants in supraventricular tachycardia: a multicenter study. Clin Cardiol. 2020;43(7):812–818. doi:10.1002/clc.23370.

Al-Zaiti SS, Najjar S, Ramaraju S, et al. Clinical features that distinguish cardiac arrhythmias from panic attacks in the emergency department. Heart Lung. 2022;56:23–29. doi: 10.1016/j.hrtlng.2022.01.002.

Farooq S, Ahmed S, Khan H, et al. Cardiac disorders misdiagnosed as anxiety: prevalence, causes and consequences. Gen Hosp Psychiatry. 2023; 81:52–58. doi: 10.1016/j.genhosppsych. 2023.01.006.

Kesler K, Lahham S. Tachyarrhythmia in Wolff-Parkinson-White syndrome. West J Emerg Med. 2016;17(4):469–470. doi:10.5811/westjem.2016.4.30323.

Sharma V, Singh S, Mehta M, Yadav D. Wolff–Parkinson–White syndrome presenting as panic disorder: a case report and literature review. J Family Med Prim Care. 2022;11(2):957–960. doi: 10.4103/jfmpc.jfmpc_1032_21.

Montoya CE, Salazar C, Correa AM. Palpitaciones y su abordaje en medicina general: revisión narrativa. Rev Colomb Cardiol. 2021;28(5):438–444. doi:10.1016/j.rccar.2020.06.004.

Steiner T, Stegemann E, Williams M, et al. Palpitations in primary care: diagnostic yield and management strategies. Br J Gen Pract. 2020;70(695):e466–e473. doi:10.3399/bjgp20X710957.

Ter Avest E, de Vries J, Stassen PM. Use of the electrocardiogram in primary care triage: a systematic assessment. Fam Pract. 2022;39(2):234–240. doi:10.1093/fampra/cmab105.

Hwang JK, O’Neill J, Bunch TJ, et al. Intermittent preexcitation: clinical characteristics and implications for risk stratification. Heart Rhythm. 2021;18(12):2009–2017. doi: 10.1016/j.hrthm.2021.08.014.

Muser D, Kosiuk J, Sommer P, et al. Risk stratification in asymptomatic Wolff-Parkinson-White pattern: insights from a contemporary cohort. Europace. 2019;21(1):104–112. doi:10.1093/europace/euy231.

Sherdia A, Abdelaal SA, Hasan MT, et al. Success rate of radiofrequency catheter ablation in Wolff-Parkinson-White syndrome patients: a systematic review and meta-analysis. Indian Heart J. 2023;75(1):1–9. doi: 10.1016/j.ihj.2023.05.010.

Raviele A, Padeletti L, Gaita F. Long-term outcomes after catheter ablation of accessory pathways: a contemporary review. Arrhythm Electrophysiol Rev. 2020;9(3):88–94. doi:10.15420/aer.2020.8.

Skov MW, Thøgersen AM, Hansen J, et al. Electrocardiographic preexcitation and risk of sudden cardiac death: systematic review and meta-analysis. Circ Arrhythm Electrophysiol. 2017;10(3): e004778. doi:10.1161/CIRCEP.116.004778.

Laaouaj J, Jacques F, O’Hara G, et al. Wolff-Parkinson-White as a bystander in a patient with aborted sudden cardiac death. HeartRhythm Case Rep. 2016;2(5):399–403. doi:10.1016/j.hrcr.2016.05.004.